Anne-Marie Mastraccio has a robust background in both healthcare and public service. She began her career as a dental hygienist before transitioning into optometry, where she has worked for over four decades. Mastraccio has also been an elected official for over three decades, culminating in her role as mayor of Sanford. She has served in the Maine House of Representatives since 2012, where she has focused on health coverage, insurance, and financial services. Mastraccio chaired the Government Oversight Committee, emphasizing accountability and efficient use of public funds.

Anne-Marie Mastraccio's political identity is marked by a blend of local pragmatism and ideological agility, particularly evident in her economic policy stances. Her legislative efforts to reverse minimum wage increases for tipped workers suggest a calculated approach to balancing labor rights with regional economic considerations. Mastraccio's commitment to improving access to skills training for unemployed workers indicates a forward-thinking strategy to address long-term economic disparities. Her leadership in government oversight underscores a commitment to efficiency and accountability, revealing a nuanced understanding of fiscal responsibility. This combination of roles and policy positions presents an intriguing dynamic in her political philosophy.