Blake Sanders holds a Bachelor of Science degree from Clemson University. He began his public service career on the Town Council of W. Pelzer, where he served for four years. Sanders then transitioned to the role of Mayor of the Town of W. Pelzer, maintaining this position for nearly eight years. In November 2023, he announced his candidacy for the South Carolina House of Representatives, where he was subsequently elected in 2024.

Blake Sanders's legislative record reveals a highly polarizing approach to social issues, particularly in healthcare. His sponsorship of the South Carolina Prenatal Equal Protection Act of 2023, which sought to make women who had abortions eligible for the death penalty, demonstrates an ideologically rigid stance on reproductive rights. Garnering support from 21 Republican co-sponsors, this bill highlights Sanders's willingness to align with extreme positions, raising questions about how he reconciles such controversial measures with broader political pragmatism. Blake Sanders's political identity is marked by a calculated, if contentious, strategy that blends deeply conservative values with a surprising ability to mobilize a significant factional base.