David P. Thompson began his career by contributing to the development of Oregon's infrastructure, including the first railroad around Willamette Falls and public land surveying. He served in the United States Army during the Civil War, reaching the rank of captain in the First Oregon Cavalry. Thompson held various political positions, including serving in the Oregon State Senate and as Mayor of Portland. He was appointed governor of Idaho Territory by President Ulysses S. Grant and later served as United States minister to the Ottoman Empire under President Benjamin Harrison.

David P. Thompson's political identity is marked by a fluid ideological positioning, having served in the Oregon State Senate as both a Republican and a Democrat. His strategic approach is evident in his advocacy for infrastructure development, particularly in railroads and public land surveying, despite his varied business interests. Thompson's rhetorical style combines a pragmatic focus on regional industrial interests with surprising alliances on environmental regulations. His diplomatic career, including his appointment as United States minister to the Ottoman Empire, further highlights his ability to navigate complex political landscapes.