Frederick O. Prince graduated from Harvard College and was admitted to the bar. He began his political career by serving in the Massachusetts House of Representatives and later the Massachusetts Senate. Prince transitioned from the Whig Party to the Democratic Party, playing a significant role as the secretary of the Democratic National Convention. His career highlights include participation in the Massachusetts Constitutional Convention and involvement in economic reform efforts.

Frederick O. Prince's political identity is marked by a strategic adaptability, transitioning from the Whig Party to the Democratic Party during pivotal moments in American history. His involvement in the Massachusetts Constitutional Convention of 1853 and subsequent advocacy for constitutional reforms illustrate a commitment to systemic change. Prince's legislative efforts in economic reform, though not extensively detailed, hint at a nuanced approach to fiscal policy. His long-term service as secretary of the Democratic National Convention underscores a deep, consistent engagement with party leadership. This blend of historical participation and ideological fluidity makes Prince's political journey both intriguing and conceptually rich.