George T. Mickelson graduated from the University of South Dakota School of Law and embarked on a career in public service, serving as State's Attorney for Walworth County and later as a member of the South Dakota House of Representatives, where he became Speaker. He then held the position of South Dakota Attorney General and subsequently served as Governor of South Dakota. Mickelson transitioned to the federal judiciary, being appointed to the United States District Court for the District of South Dakota and later confirmed as Chief Judge, a role he maintained until his death.

George T. Mickelson's political career reveals a figure who adeptly navigated various roles, from state attorney to federal judge. His legislative record shows an unexpected convergence with opposing factions on environmental regulations, revealing a highly calculated approach to protecting regional industrial interests. Mickelson's judicial appointments suggest a commitment to maintaining a balanced federal judiciary, yet his political maneuvers hint at a nuanced understanding of regional dynamics. This blend of judicial restraint and political agility makes his ideological positioning both intriguing and multifaceted.