Spencer Wetmore graduated from Princeton University and subsequently earned a law degree from Vanderbilt University Law School. Wetmore was admitted to the South Carolina Bar and began a career in public service as a prosecutor. They held leadership roles in local government, including City Administrator and City Manager for Folly Beach. Wetmore has experience in economic development, environmental policy, and public safety, and has emphasized the importance of education and healthcare in their professional and personal life.

Spencer Wetmore combines a commitment to economic growth with a focus on environmental sustainability, suggesting a nuanced approach to balancing development and conservation. Her advocacy for affordable healthcare and public education investment indicates a progressive stance on social issues, yet her background as a prosecutor hints at a pragmatic approach to criminal justice. Wetmore's policy positions reveal an intriguing blend of progressive ideals and a practical, results-oriented mindset.