George F. Talbot graduated from Bowdoin College and earned a Master of Arts degree from the same institution. He began his career as an attorney and held various local offices, including Superintendent of Schools and County Attorney for Washington County. Talbot transitioned into national politics as a member of the Free Soil Party and later became a Republican, participating in conventions that led to the nomination of Abraham Lincoln. He served as United States Attorney for Maine and later as Solicitor of the Treasury. Additionally, Talbot authored works on religious studies and literature.

George F. Talbot's political identity is marked by a distinctive blend of local advocacy and national engagement. His career, from local offices to national conventions, showcases a deeply rooted commitment to regional interests. Talbot's legislative focus on local businesses and education underscores a highly localized approach to governance. His unexpected interest in religious studies, reflected in his authored book, adds an atypical dimension to his ideological profile. This combination of localism and an unconventional intellectual pursuit presents a nuanced political figure whose motivations warrant further exploration.